Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (11): 869-872.doi: 10.3760/cma.j.issn.1673422X.2015.11.020

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Mechanisms of perineural invasion and its effect on early cervical cancer

Xia Fang, Xue Xiuhua, Zhang Ping.   

  1. Department of Gynecology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao 266000, China
  • Online:2015-11-08 Published:2015-09-30
  • Contact: Zhang Ping E-mail:zpskx001@163.com

Abstract: Mechanisms of perineural invasion may include the effect of microenvironment, the interaction of cancer cell and nerve, the action of stromal cell and cancer cell, signal transduction between the cancer cell and nerve by the involvement of the neurotrophin and its receptor, chemokines and its receptor. Its impacts on early cervical cancer include surgery, adjuvant therapy, prognosis and so on.

Key words: Neoplasms, nerve tissue, Neoplasm invasiveness, Uterine cervical neoplasms