Progress on antiangiogenesis treating head and neck squamous cell carcinoma

doi:10.3760/cma.j.issn.1673422X.2015.08.016

Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (8): 619-621.doi: 10.3760/cma.j.issn.1673422X.2015.08.016

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Progress on antiangiogenesis treating head and neck squamous cell carcinoma

SHANG Yi-Tai, LI Xiao-Jiang

Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Research Center of Head and Neck Tumor, Yunnan Province, Kunming 650118, China

Online:2015-08-08 Published:2015-06-29
Contact: Li Xiaojiang E-mail:wingman11@163.com

Abstract

Abstract: Current treatment strategies for recurrent or metastatic head and neck squamous cell carcinoma（HNSCC） include palliative chemotherapy and antiEGFR targeted agents. Angiogenesis is crucial both for the growth of a primary tumor and the development of distant metastasis. Therefore, the angiogenesis factors and their receptors become the targets of therapeutic agents. Current antiangiogenesis drugs achieve the purpose of treatment mainly by blocking VEGFVEGFR pathways. And it gets certain effects in clinical trials for the treatment of HNSCC. Antiangiogenesis therapy will provide more choices for treating HNSCC.

Key words: Head and neck neoplasms, Angiogenesis inhibitors, Vascular endothelial growth factor A

SHANG Yi-Tai, LI Xiao-Jiang. Progress on antiangiogenesis treating head and neck squamous cell carcinoma[J]. Journal of International Oncology, 2015, 42(8): 619-621.

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Progress on antiangiogenesis treating head and neck squamous cell carcinoma

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