Abstract: miR200c is a member of miR200 family, and it plays an important role in tumor diagnosis, metastasis and chemoresistance. miR200c is identified as a molecular marker and prognostic indicator in cancer screening. It can inhibit epithelialmesenchymal transition, tumor invasion and metastasis, and increase the chemosensitivity of tumor cells, but the relevant mechanism is still not fully clear. The studies of miR200c and some factors in regulatory pathway are beneficial to promote its applications in clinical diagnosis.

Key words: MicroRNAs, Neoplasms, Epithelialmesenchymal transition