Abstract: As a result, establishing animal models of liver cancer is of high value. There are two parts of the establishment of animal models—the selection of laboratory animals and the source of tumors.  The animal models could be classified into different patterns due to difference sources of tumor, and these different patterns possess distinctive characters and limitations. The ideally animal models should satisfy the general requirements of biological habits, biochemical properties, and pathological features which are similar with human hepatocellular and  easy to establish.

Key words: Liver neoplasms, Models, animal