Abstract: CENPF is a cellcycle dependent kinetochore protein, whose expression and localization patterns are regulated in a cell cycledependent manner. CENPF plays an important role in the development and progress of malignant tumor. The expression of CENPF is upregulated in many tumors. It serves as an important marker in cell proliferation. Studies have demonstrated that CENPF is involved in tumor genesis, progress, invasiveness, relapse and prognosis. CENPF might be a valuable prognostic marker and potential therapy target in cancer treatment.

Key words: Neoplasms, Prognosis, Centromere protein F