Abstract: Nucleobindin 2 protein(NUCB2) is a newly discovered neuropeptide precursor protein, which has a comprehensive cytology function and is expressed in the hypothalamus nucleus and many peripheral tissues. There aren′t many studies about its signaling pathway, where neuroendocrine regulation, cell survival growth, tumor suppressor, cytokine secretion were found to involve in it. Besides, it has also been confirmed that breast cancer, lung cancer, ovarian cancer and prostate cancer are closely related to NUCB2. Therefore, several downstream pathways of NUCB2 may be related to the formation and progression of tumor. Further studies are still needed to clarify the signal pathways of NUCB2 to provide a reliable basis for clinical cancer prevention.

Key words: Histones, Neoplasms, Nesfatin1