Journal of International Oncology ›› 2014, Vol. 41 ›› Issue (7): 484-487.doi: 10.3760/cma.j.issn.1673422X.2014.07.002

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EML4ALK fusion gene in tumor

 GUO  Yi-Nan, YUE  Wen-Tao   

  1. Department of Cellular & Molecular Biology,Tuberculosis and Thoracic Tumor Research Institute,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: YUE Wen-Tao E-mail:yuewt2000@yahoo.com

Abstract: EML4ALK fusion gene is one of the novel targets in the therapy of lung cancer, which can be detected in several kinds of tumors. A specific ALK inhibitor has been shown to exert antitumor effects in nonsmall cell lung cancer with the EML4ALK fusion gene. Correlative study between EML4ALK gene fusion and EGFRKras mutations might cast new insight on the tumor target therapy.

Key words: Neoplasms, EML4ALK fusion gene