Journal of International Oncology ›› 2014, Vol. 41 ›› Issue (6): 458-460.doi: 10.3760/cma.j.issn.1673422X.2014.06.017
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WANG Ling, JIN Ping
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Abstract: DNMT1，the main member of the DNA methyltransferase (DNMT) family, plays a core role in maintaining and regulating tumor cell genomewide and the local area methylation. DNMT1 is highly expressed in gynecological malignancies, which leads to abnormal DNA methylation of genes, especially high methylation of tumor suppressor genes, gene expression silencing, and malignant cell growth.
Key words: Sitespecific DNA methyltransferase (cytosinespecific), Genital neoplasms,female
WANG Ling, JIN Ping. DNA methyctransferase 1 and gynecological malignancies[J]. Journal of International Oncology, 2014, 41(6): 458-460.
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URL: https://gjzlx.sdfmu.edu.cn/EN/10.3760/cma.j.issn.1673422X.2014.06.017
https://gjzlx.sdfmu.edu.cn/EN/Y2014/V41/I6/458
