Abstract: K-ras gene is one of oncogenes in nonsmall cell lung cancer, and it can promote tumor cells growth after mutations by several signaling pathways. Kras mutations frequently occur in lung adenocarcinoma patients with smoking history. In the present study, Kras mutations are associated with resistence to targated therapy and may be a marker of poor prognosis in patients with nonsmall cell lung cancer.

Key words: Carcinoma, nonsmallcell lung, Prognosis, Drug resistance, neoplasm, Kras gene