Regulatory mechanism of SNX family in tumor genesis and development

doi:10.3760/cma.j.issn.1673-422X.2018.12.007

Abstract

Abstract: The sorting nexin (SNX) family is a class of functional proteins involved in protein sorting and transfer. A total of 33 members are involved in the regulation of life activities in mammal. SNX family expresses abnormally in a variety of tumors, including colorectal cancer, gastric cancer, liver cancer, thyroid cancer, lung cancer, breast cancer, cervical cancer, et al. SNX family plays important roles in tumor genesis, development, invasion, metastasis, prognosis and chemotherapy resistance by sorting and transfer of key proteins regulating tumor activity, and provides a new way for the treatment of tumors.

Key words: Neoplasms, Sorting nexin

Hu Bo, Lu Jibin. Regulatory mechanism of SNX family in tumor genesis and development[J]. Journal of International Oncology, 2018, 45(12): 735-738.

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