Adverse reactions and symptomatic treatment of immunological checkpoint inhibitors in tumor therapy

doi:10.3760/cma.j.issn.1673-422X.2017.11.014

Abstract

Abstract: Immunological checkpoint inhibitors include monoclonal antibodies of cytotoxic T lymphocyte antigen4 (CTLA4) and programmed cell death1 (PD1). AntiCTLA4 drug ezetimab (ipilimumab) and antiPD1 drug (pembrolizumab and nivolumab) are approved for the treatment of melanoma and nonsmall cell lung cancer. The effects of these drugs on renal cell carcinoma, bladder cancer, breast cancer, gastrointestinal cancer and other types of cancers are still in largescale clinical trials. These drugs have good effects in the clinical application, but they inevitably lead to many adverse reactions.

Key words: Neoplasms, Immunological checkpoint inhibitors

周丽娜，李红梅. Adverse reactions and symptomatic treatment of immunological checkpoint inhibitors in tumor therapy[J]. Journal of International Oncology, 2017, 44(11): 860-863.

References

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