Reversal of Pglycoproteinmediated multidrug resistance mechanism by curcumin

doi:10.3760/cma.j.issn.1673-422X.2017.10.009

Abstract

Abstract: Multidrug resistance (MDR) is one of the important reasons for the failure of clinical anticancer drugs, involving multiple mechanisms. Among them, the classical MDR mechanism mediated by Pglycoprotein (Pgp) is closely related to the formation of MDR, which can excrete intracellular chemotherapeutic drugs through the "drug pump" effect and significantly reduce the therapeutic effect. Curcumin is mainly extracted from the underground rhizome of Chinese medicine turmeric, with a wide range of pharmacological activity. Recent studies have found that curcumin also has a role in reversing the MDR of the tumor, by inhibiting both Pgp function and expression, and this process involves a variety of signal paths.

Key words: Curcumin, P-glycoprotein, Multidrug resistance, Signal path

Liu Lan, Zhang Zhimin, Peng Wenmiao, Fu Hongxing, Rao Zhiguo. Reversal of Pglycoproteinmediated multidrug resistance mechanism by curcumin[J]. Journal of International Oncology, 2017, 44(10): 758-761.

References

［1］ Wu Q, Yang Z, Nie Y, et al. Multidrug resistance in cancer chemotherapeutics: mechanisms and lab approaches［J］. Cancer Lett, 2014, 347(2): 159166. DOI: 10.1016/j.canlet.2014.03.013. ［2］ Silva R, VilasBoas V, Carmo H, et al. Modulation of Pglycoprotein efflux pump: induction and activation as a therapeutic strategy［J］. Pharmacol Ther, 2015, 149(2): 1123. DOI: 10.1016/j.pharmthera.2014.11.013. ［3］ Loo TW, Clarke DM. PGlycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface［J］. Biochem Biophys Res Commun, 2016, 472(2): 379383. DOI: 10.1016/j.bbrc.2016.02.124. ［4］ Bugde P, Biswas R, Merien F, et al. The therapeutic potential of targeting ABC transporters to combat multidrug resistance［J］. Expert Opin Ther Targets, 2017, 21(5): 511530. DOI: 10.1080/14728222.2017.1310841. ［5］ Teng YN, Hsieh YW, Hung CC, et al. Demethoxycurcumin modulates human Pglycoprotein function via uncompetitive inhibition of ATPase hydrolysis activity［J］. J Agric Food Chem, 2015, 63(3): 847855. DOI: 10.1021/jf5042307. ［6］ Sreenivasan S, Ravichandran S, Vetrivel U, et al. Modulation of multidrug resistance 1 expression and function in retinoblastoma cells by curcumin［J］. J Pharmacol Pharmacother, 2013, 4(2): 103109. DOI: 10.4103/0976500X.110882. ［7］ Prasad N, Sudhakar YA, Kanwar JR. Curcumin regulates colon cancer by inhibiting Pglycoprotein in insitu cancerous colon perfusion rat model［J］. J Cancer Sci Ther, 2014, 5(9): 313319. DOI: 10.4172/19485956.1000221. ［8］ Shah K, Mirza S, Desai U, et al. Synergism of curcumin and cytarabine in the down regulation of multidrug resistance genes in acute myeloid leukemia［J］. Anticancer Agents Med Chem, 2016, 16(1): 128135. DOI: 10.2174/1871520615666150817115718. ［9］ Si M, Zhao J, Li X, et al. Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of Pglycoprotein［J］. Chin Med J, 2013, 126(21): 41164123. DOI: 10.3760/cma.j.issn.03666999.20130950. ［10］ Yao J, Wei X, Lu Y. Chaetominine reduces MRP1mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells［J］. Biochem Biophys Res Commun, 2016, 473(4): 867873. DOI: 10.1016/j.bbrc.2016.03.141. ［11］ Wang L, Wang C, Jia Y, et al. Resveratrol increases antiproliferative activity of bestatin through downregulating Pglycoprotein expression via inhibiting PI3K/Akt/mTOR pathway in K562/ADR cells［J］. J Cell Biochem, 2015, 117(5): 12331239. DOI: 10.1002/jcb.25407. ［12］ Barancík M, Bohácová V, Sedlák J, et al. LY294, 002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes Pglycoproteinmediated multidrug resistance［J］. Eur J Pharm Sci, 2006, 29(5): 426434. DOI: 10.1016/j.ejps.2006.08.006. ［13］ Choi BH, Kim CG, Lim Y, et al. Curcumin downregulates the multidrugresistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway［J］. Cancer Lett, 2008, 259(1): 111118. DOI: 10.1016/j.canlet.2007.10.003. ［14］金鑫. 姜黄素联合吉非替尼对非小细胞肺癌NCIH1975作用及机制研究［D］. 杭州: 浙江大学, 2016. ［15］ Zhang X, Xiao W, Wang L, et al. Deactivation of signal transducer and activator of transcription 3 reverses chemotherapeutics resistance of leukemia cells via downregulating Pgp［J］. PLoS One, 2011, 6(6): e20965. DOI: 10.1371/journal.pone.0020965. ［16］ Ji T, Gong D, Han Z, et al. Abrogation of constitutive Stat3 activity circumvents cisplatin resistant ovarian cancer［J］. Cancer lett, 2013, 341(2): 231239. DOI: 10.1016/j.canlet.2013.08.022. ［17］ Wen K, Fu Z, Wu X, et al. Oct4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: effects associated with STAT3/Survivin［J］. Cancer Lett, 2013, 333(1): 5665. DOI: 10.1016/j.canlet.2013.01.009. ［18］文坤明, 冷敏, 程家平, 等. 姜黄素通过抑制STAT3通路调控人结肠癌耐奥沙利铂细胞株的耐药性［J］. 中国免疫学杂志, 2015(8): 10561059. DOI: 10.3969/j.issn.1000484X.2015.08.012. ［19］ Zhang W, Guo J, Li S, et al. Discovery of monocarbonyl curcuminBTP hybrids as STAT3 inhibitors for drugsensitive and drugresistant breast cancer therapy［J］. Sci Rep, 2017, 7: 46352. DOI: 10.1038/srep46352. ［20］ Guan H, Zhao P, Dai Z, et al. SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/Pglycoprotein via EGFR/ERK/AP1 pathway［J］. Tumour Biol, 2016, 37(9): 1215312160. DOI: 10.1007/s1327701650920. ［21］ Guo X, Ma N, Wang J, et al. Increased p38MAPK is responsible for chemotherapy resistance in human gastric cancer cells［J］. BMC Cancer, 2008, 8: 375. DOI: 10.1186/147124078375. ［22］王志君. 姜黄素对紫杉醇耐药卵巢癌细胞SKOV3/Taxol25的逆转增效作用及其机理的研究［D］. 苏州: 苏州大学, 2015. ［23］ Chen P, Li J, Jiang HG, et al. Curcumin reverses cisplatin resistance in cisplatinresistant lung caner cells by inhibiting FA/BRCA pathway［J］. Tumour Biol, 2015, 36(5): 35913599. DOI: 10.1007/s1327701429964. ［24］ Liang Y, Zheng T, Song R, et al. Hypoxiamediated sorafenib resistance can be overcome by EF24 through Von HippelLindau tumor suppressordependent HIF1α inhibition in hepatocellular carcinoma［J］. Hepatology, 2013, 57(5): 18471857. DOI: 10.1002/hep.26224. ［25］ Muddineti OS, Kumari P, Ghosh B, et al. dαTocopheryl succinate/phosphatidyl ethanolamine conjugated amphiphilic polymerbased nanomicellar system for the efficient delivery of curcumin and to overcome multiple drug resistance in cancer［J］. ACS Appl Mater Interfaces, 2017, 9(20): 1677816792. DOI: 10.1021/acsami.7b01087.

[1]	Li Yuxiang, Wang Xinwen. Interferon-related signaling pathways and clinical application in tumor therapy [J]. Journal of International Oncology, 2020, 47(6): 364-367.
[2]	Ling Xiaofei, Xu Ke, Shao Hua, Wang Cuijuan. Anticancer mechanism and application of curcumin analog EF24 [J]. Journal of International Oncology, 2018, 45(3): 172-175.
[3]	Xiaoliang, Luo Xu, Liu Ruming. Expression and relationship between hepaCAM protein and multidrug resistance protein in renal carcinoma [J]. Journal of International Oncology, 2016, 43(8): 584-587.
[4]	Cai Xiaojun, Han Lijuan, Wei Ping. Curcumin downregulation of MGMT expression to enhance the chemosensitivity of temozolomide on maligant glioblastoma [J]. Journal of International Oncology, 2016, 43(8): 565-569.
[5]	Tian Ruonan,Sun Jianjing, Zhang Linxi. Mechanism of curcumin resisting esophageal cancer [J]. Journal of International Oncology, 2016, 43(5): 379-381.
[6]	Chen Ying, Zhang Xingping. Reversing methods of tumor multidrug resistance [J]. Journal of International Oncology, 2016, 43(5): 364-367.
[7]	LIU Dong-Ju, ZHAO Qiu-Sheng, YAO Yu. Effects of curcumin combined with cisplatin on growth and lymphatic metastasis of cervical cancer xenografts in nude mice [J]. Journal of International Oncology, 2016, 43(4): 241-245.
[8]	DIAO Cun-Qi, BI Jing-Wang, WANG Bao-Cheng. Akt inhibitors in the treatment of colorectal cancer [J]. Journal of International Oncology, 2015, 42(3): 224-227.
[9]	ZHENG Ying, CHEN Qin, ZHANG Bin, CAO Xu-Chen. Roles and resistance mechanisms of survivin in tumor [J]. Journal of International Oncology, 2014, 41(4): 241-243.
[10]	DANG Jun-Qiang, CHEN Yuan, LIN Wen, LI Chang-Bin. Mechanism of phytochemicals as anticancer agents in parcreatic carcinoma [J]. Journal of International Oncology, 2014, 41(12): 930-933.
[11]	SHAO Song-Jun, ZHANG Xiang-Ning, HUANG Pei-Chun. null [J]. Journal of International Oncology, 2013, 40(7): 494-497.
[12]	YANG Lu-Lu, LIU Xin. Resistance mechanisms and the countermeasures of acute leukemia [J]. Journal of International Oncology, 2013, 40(5): 377-380.
[13]	ZHU Jun, YUE Wen-Tao. Tumor associated gene PFTK1 [J]. Journal of International Oncology, 2013, 40(2): 100-102.
[14]	HAN Jin-Rong, ZHANG Lin-Xi. Effect and mechanism of curcumin on antitumor [J]. Journal of International Oncology, 2013, 40(11): 823-826.
[15]	LIU Qin-Qin, GUO Dong-Mei, TENG Qing-Liang. Notch signal pathway and the pathogenesis of multiple myeloma [J]. Journal of International Oncology, 2012, 39(7): 544-546.