Mechanism of exosome in the pathogenesis of breast cancer

doi:10.3760/cma.j.issn.1673-422X.2016.06.017

Abstract

Abstract: Researches show that exosome can take park in the development and progression of breast cancer by means of mediating the intercellular communication， which can promote cancer metastasis and drug resistance, thus influencing the treatment effect of patients with cancers. Exosome is closely related with clinical stage and prognosis of breast cancer, which has a potential value in the early diagnosis and biological therapy of breast cancer and provides a new hope for the treatment of breast cancer.

Key words: Breast neoplasms, Neoplasm metastasis, Exosomes

Yan Fei, Yu Shaorong, Cao Haixia, Feng Jifeng. Mechanism of exosome in the pathogenesis of breast cancer[J]. Journal of International Oncology, 2016, 43(6): 462-464.

References

［1］ Lowry MC, Gallagher WM, O′Driscoll L. The role of exosomes in breast cancer［J］. Clin Chem, 2015, 61(12): 1457-1465. DOI: 10.1373/clinchem.2015.240028. ［2］ Villagrasa A, lvarez PJ, Osuna A, et al. Exosomes derived from breast cancer cells, small trojan horses?［J］. J Mammary Gland Biol Neoplasia, 2014, 19(34): 303-313. DOI: 10.1007/s10911-015-9332-5. ［3］ Xu R, Greening DW, Rai A, et al. Highlypurified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct［J］. Methods, 2015, 87: 11-25. DOI: 10.1016/j.ymeth.2015.04.008. ［4］ Sun Y, Liu J. Potential of cancer cellderived exosomes in clinical application: a review of recent research advances［J］. Clin Ther, 2014, 36(6): 863-872. DOI: 10.1016/j.clinthera.2014.04.018. ［5］ Hsu C, Morohashi Y, Yoshimura S, et al. Regulation of exosome secretion by Rab35 and its GTPaseactivating proteins TBC1D10AC［J］. J Cell Biol, 2010, 189(2): 223-232. DOI: 10.1083/jcb.200911018. ［6］ Cai Z, Yang F, Yu L, et al. Activated T cell exosomes promote tumor invasion via Fas signaling pathway［J］. J Immunol, 2012, 188(12): 59545961. DOI: 10.4049/jimmunol.1103466. ［7］ Yuyama K, Sun H, Mitsutake S, et al. Sphingolipidmodulated exosome secretion promotes clearance of amyloidbeta by microglia［J］. J Biol Chem, 2012, 287(14): 10977-10989. DOI: 10.1074/jbc.M111.324616. ［8］ Ge Q, Zhou Y, Lu J, et al. miRNA in plasma exosome is stable under different storage conditions［J］. Molecules, 2014, 19(2): 1568-1575. DOI: 10.3390/molecules19021568. ［9］ O′Brien K, Rani S, Corcoran C, et al. Exosomes from triplenegative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells［J］. Eur J Cancer, 2013, 49(8): 1845-1859. DOI: 10.1016/j.ejca.2013.01.017. ［10］ Tang XJ, Sun XY, Huang KM, et al. Therapeutic potential of CART cellderived exosomes: a cellfree modality for targeted cancer therapy ［J］. Oncotarget, 2015, 6(42): 44179-44190. DOI: 10.18632/oncotarget.6175. ［11］ Ostenfeld MS, Jeppesen DK, Laurberg JR, et al. Cellular disposal of miR23b by RAB27dependent exosome release is linked to acquisition of metastatic properties［J］. Cancer Res, 2014, 74(20): 5758-5771. DOI: 10.1158/00085472.CAN-13-3512. ［12］ Thompson CA, Purushothaman A, Ramani VC, et al. Heparanase regulates secretion, composition, and function of tumor cellderived exosomes［J］. J Biol Chem, 2013, 288(14): 10093-10099. DOI: 10.1074/jbc.C112.444562. [13] Wang L, Xie Y, Ahmed KA, et al. Exosomal pMHC-I complex targets T cell-based vaccine to directly stimulate CTL responses leading to antitumor immunity in transgenic FVBneuN and HLA-A2/HER2 mice and eradicating trastuzumab-resistant tumor in athymic nude mice[J]. Breast Cancer Res Treat, 2013, 140(2): 273-284. DOI: 10.1007/s10549-013-2626-7. ［14］ Higginbotham JN, Demory Beckler M, Gephart JD, et al. Amphiregulin exosomes increase cancer cell invasion［J］. Curr Biol, 2011, 21(9): 779-786. DOI: 10.1016/j.cub.2011.03.043. ［15］ Singh R, Pochampally R, Watabe K, et al. Exosomemediated transfer of miR10b promotes cell invasion in breast cancer［J］. Mol Cancer, 2014, 13：256. DOI: 10.1186/1476-4598-13-256. ［16］ Luga V, Zhang L, ViloriaPetit AM, et al. Exosomes mediate stromal mobilization of autocrine WntPCP signaling in breast cancer cell migration［J］. Cell, 2012, 151(7): 1542-1556. DOI: 10.1016/j.cell.2012.11.024. ［17］ Zhou W, Fong MY, Min Y, et al. Cancersecreted miR105 destroys vascular endothelial barriers to promote metastasis［J］. Cancer Cell, 2014, 25(4): 501-515. DOI: 10.1016/j.ccr.2014.03.007. ［18］ Ciravolo V, Huber V, Ghedini GC, et al. Potential role of HER2overexpressing exosomes in countering trastuzumabbased therapy［J］. J Cell Physiol, 2012, 227(2): 658-667. DOI: 10.1002/jcp.22773. ［19］ Wei Y, Lai X, Yu S, et al. Exosomal miR221/222 enhances tamoxifen resistance in recipient ERpositive breast cancer cells［J］. Breast Cancer Res Treat, 2014, 147(2): 423-431. DOI: 10.1007/s10549-014-3037-0. ［20］ Zeitzer JM, Nouriani B, Neri E, et al. Correspondence of plasma and salivary cortisol patterns in women with breast cancer［J］. Neuroendocrinology, 2014, 100(23): 153-161. DOI: 10.1159/000367925. ［21］ Lau CS, Wong DT. Breast cancer exosomelike microvesicles and salivary gland cells interplay alters salivary gland cellderived exosomelike microvesicles in vitro［J］. PLoS One, 2012, 7(3): e33037. DOI: 10.1371/journal.pone.0033037. ［22］ Khan S, Bennit HF, Turay D, et al. Early diagnostic value of survivin and its alternative splice variants in breast cancer［J］. BMC Cancer, 2014, 14：176. DOI: 10.1186/1471-2407-14-176.

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