Research progress of Wnt/β-catenin signaling pathway in tumor drug resistance

doi:10.3760/cma.j.issn.1673-422X.2016.06.015

Abstract

Abstract: Wnt/β-catenin signaling pathway participates in cancer cell proliferation, invasion and metastasis and effectively induces drug resistance. It is also the key signal to mediate cancer carcinogenesis. Recent studies in vitro indicate that disturbance of Wnt/βcatenin signaling pathway can increase the sensitivity of the cancer cells to chemotherapeutic drugs. Indepth researches and analysis of tumor drug resistance induced by Wnt/β-catenin will provide potential targets and possible therapeutic means for the treatment of tumors.

Key words: Neoplasms, Drug tolerance, Wnt/β-catenin signaling pathway

Yi Zhigang, Zhou Kaisheng, Pu Yanchuan, Wang Xingwen, Wang Shuanke. Research progress of Wnt/β-catenin signaling pathway in tumor drug resistance[J]. Journal of International Oncology, 2016, 43(6): 455-457.

References

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