Expression and role of HOXC gene in tumor

doi:10.3760/cma.j.issn.1673-422X.2016.06.009

Abstract

Li Lin, Jia Xiuhong. Expression and role of HOXC gene in tumor[J]. Journal of International Oncology, 2016, 43(6): 436-438.

［1］ Durston AJ, Jansen HJ, In der Rieden P, et al. Hox collinearitya new perspective［J］. Int J Dev Biol, 2011, 55(10-12): 899-908. DOI: 10.1387/ijdb.113358ad. ［2］ Tosi′c N, Stojiljkovi′c M, Colovi′c N, et al. Acute myeloid leukemia with NUP98HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review［J］. Cancer Genet Cytogenet, 2009, 193(2): 98-103. DOI: 10.1016/j.cancergencyto.2009.03.007. ［3］ Wan Y, Chang HY. HOTAIR: Flight of noncoding RNAs in cancer metastasis［J］. Cell Cycle, 2010, 9(17): 3391-3392. ［4］ Shah N, Sukumar S. The Hox genes and their roles in oncogenesis［J］. Nat Rev Cancer, 2010, 10(5): 361-371. DOI: 10.1038/nrc2826. ［5］ He S, Liu S, Zhu H. The sequence, structure and evolutionary features of HOTAIR in mammals［J］. BMC Evol Biol, 2011, 11: 102. ［6］ Xing CY, Hu XQ, Xie FY, et al. Long noncoding RNA HOTAIR modulates cKIT expression through sponging miR193a in acute myeloid leukemia［J］. FEBS Lett, 2015, 589(15): 1981-1987. DOI: 10.1016/j.febslet.2015.04.061. ［7］ Ansari KI, Hussain I, Shrestha B, et al. HOXC6 is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment［J］. J Mol Biol, 2011, 411(2): 334349. DOI: 10.1016/j.jmb.2011.05.050. ［8］ Hur H, Lee JY, Yun HJ, et al. Analysis of HOX gene expression patterns in human breast cancer［J］. Mol Biotechnol, 2014, 56(1): 64-71. DOI: 10.1007/s1203301396824. ［9］ Wu Y, Liu J, Zheng Y, et al. Suppressed expression of long noncoding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells［J］. Tumour Biol, 2014, 35(12): 11887-11894. DOI: 10.1007/s13277-014-2453-4. ［10］ Pei CS, Wu HY, Fan FT, et al. Influence of curcumin on HOTAIRmediated migration of human renal cell carcinoma cells［J］. Asian Pac J Cancer Prev, 2014, 15(10): 4239-4243. ［11］ Cantile M, Franco R, Schiavo G, et al. The HOX genes network in urogenital cancers: mechanisms and potential therapeutic implications［J］. Curr Med Chem, 2011, 18(32): 4872-4884. ［12］ Liu YJ, Zhu Y, Yuan HX, et al. Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis［J］. Tumour Biol, 2015, 36(4): 2821-2829. DOI: 10.1007/s13277-014-2909-6. ［13］ Chiyomaru T, Yamamura S, Fukuhara S, et al. Genistein inhibits prostate cancer cell growth by targeting miR34a and oncogenic HOTAIR［J］. PLoS One, 2013, 8(8): e70372. DOI: 10.1371/journal.pone.0070372. ［14］ Axlund SD, Lambert JR, Nordeen SK. HOXC8 inhibits androgen receptor signaling SRC-3 recruitment to direct androgen target genes［J］. Mol Cancer Res, 2010, 8(12): 1643-1655. ［15］王刘江. 前列腺癌危险度分级与术后Gleason评分、PSA的关系的研究［D］. 杭州: 浙江大学, 2013. ［16］ Waltregny D, Alami Y, Clausse N, et al. Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation［J］. Prostate, 2002, 50(3): 162-169. ［17］ Kocak H, Ackermann S, Hero B, et al. HoxC9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma［J］. Cell Death Dis, 2013, 4: e586. DOI: 10.1038/cddis.2013.84. ［18］ Mao L, Ding J, Zha Y, et al. HOXC9 links cellcycle exit and neuronal differentiation and is a prgnostic marker in neuroblastoma［J］. Cancer Res, 2011, 71(12): 4314-4324. DOI: 10.1158/0008-5472.CAN-11-0051. ［19］朱永洁, 陈鑫, 邴春梅, 等. 神经母细胞瘤组织中HOXC9蛋白的表达与肿瘤发展及预后的关系［J］. 山东医药, 2014, 54(43): 25-27. DOI: 10.3969/j.issn.1002266X.2014.43.008. ［20］ Cantile M, Galletta F, Franco R, et al. Hyperexpression of HOXC13, located in the 12q13 chromosomal region, in welldifferentiated and dedifferentiated human liposarcomas［J］. Oncol Rep, 2013, 30(6): 2579-2586. DOI: 10.3892/or.2013.2760. ［21］ Du YB, Dong B, Shen LY, et al. The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma［J］. J Surg Res, 2014, 188(2): 442-450. DOI: 10.1016/j.jss.2014.01.017. ［22］ Moon SM, Kim SA, Yoon JH, et al. HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression［J］. J Biol Chem, 2012, 287(42): 35678-35688. DOI: 10.1074/jbc.M112.361675. ［23］ Zhai Y, Kuick R, Nan B, et al. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion［J］. Cancer Res, 2007, 67(21): 10163-10172. DOI: 10.1158/00085472.CAN-07-2056. ［24］ Zhang Q, Jin XS, Yang ZY, et al. Upgredulated Hoxc6 expression is associated with poor survival in gastric cancer patients［J］. Neoplasma, 2013, 60(4): 439-445. DOI: 10.4149/neo_2013_057.

[1]	Liu Na, Kou Jieli, Yang Feng, Liu Taotao, Li Danping, Han Junrui, Yang Lizhou. Clinical value of serum miR-106b-5p and miR-760 combined with low-dose spiral CT in the diagnosis of early lung cancer [J]. Journal of International Oncology, 2024, 51(6): 321-325.
[2]	Yang Mi, Bie Jun, Zhang Jiayong, Deng Jiaxiu, Tang Zuge, Lu Jun. Analysis of the efficacy and prognosis of neoadjuvant therapy for locally advanced resectable esophageal cancer [J]. Journal of International Oncology, 2024, 51(6): 332-337.
[3]	Yuan Jian, Huang Yanhua. Diagnostic value of Hp-IgG antibody combined with serum DKK1 and sB7-H3 in early gastric cancer [J]. Journal of International Oncology, 2024, 51(6): 338-343.
[4]	Chen Hongjian, Zhang Suqing. Study on the relationship between serum miR-24-3p， H2AFX and clinical pathological features and postoperative recurrence in liver cancer patients [J]. Journal of International Oncology, 2024, 51(6): 344-349.
[5]	Guo Zehao, Zhang Junwang. Role of PFDN and its subunits in tumorigenesis and tumor development [J]. Journal of International Oncology, 2024, 51(6): 350-353.
[6]	Zhang Baihong, Yue Hongyun. Advances in anti-tumor drugs with new mechanisms of action [J]. Journal of International Oncology, 2024, 51(6): 354-358.
[7]	Xu Fenglin, Wu Gang. Research progress of EBV in tumor immune microenvironment and immunotherapy of nasopharyngeal carcinoma [J]. Journal of International Oncology, 2024, 51(6): 359-363.
[8]	Wang Ying, Liu Nan, Guo Bing. Advances of antibody-drug conjugate in the therapy of metastatic breast cancer [J]. Journal of International Oncology, 2024, 51(6): 364-369.
[9]	Zhang Rui, Chu Yanliu. Research progress of colorectal cancer risk assessment models based on FIT and gut microbiota [J]. Journal of International Oncology, 2024, 51(6): 370-375.
[10]	Gao Fan, Wang Ping, Du Chao, Chu Yanliu. Research progress on intestinal flora and non-surgical treatment of the colorectal cancer [J]. Journal of International Oncology, 2024, 51(6): 376-381.
[11]	Liu Jing, Liu Qin, Huang Mei. Prognostic model construction of lung infection in patients with chemoradiotherapy for esophageal cancer based on SMOTE algorithm [J]. Journal of International Oncology, 2024, 51(5): 267-273.
[12]	Yang Lin, Lu Ning, Wen Hua, Zhang Mingxin, Zhu Lin. Study on the clinical relationship between inflammatory burden index and gastric cancer [J]. Journal of International Oncology, 2024, 51(5): 274-279.
[13]	Wang Junyi, Hong Kaibin, Ji Rongjia, Chen Dachao. Effect of cancer nodules on liver metastases after radical resection of colorectal cancer [J]. Journal of International Oncology, 2024, 51(5): 280-285.
[14]	Zhang Ningning, Yang Zhe, Tan Limei, Li Zhenning, Wang Di, Wei Yongzhi. Diagnostic value of cervical cell DNA ploidy analysis combined with B7-H4 and PKCδ for cervical cancer [J]. Journal of International Oncology, 2024, 51(5): 286-291.
[15]	Fu Yi, Ma Chenying, Zhang Lu, Zhou Juying. Research progress of habitat analysis in radiomics of malignant tumors [J]. Journal of International Oncology, 2024, 51(5): 292-297.

Expression and role of HOXC gene in tumor

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments