Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (7): 529-531.doi: 10.3760/cma.j.issn.1673-422X.2015.07.014

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RET gene and tumor

Xie Weiwei, Chang Jianhua   

  1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China
  • Online:2015-07-08 Published:2015-05-26
  • Contact: Chang Jianhua E-mail:changjianhua@163.com

Abstract: RET gene is an important oncogene, which is closely associated with the development of various types of human tumors. The mainly mechanisms of RET gene associated tumor are mutation and overexpression of wild type. Activated RET protein participates in the proliferation, apoptosis, metastasis through some signal pathways and influences the tumorigenesis  and development.

Key words:  Neoplasms, Therapy, RET gene