Research progress of Antrodia cinnomomea on the anti-hepatocarcinoma mechanism

doi:10.3760/cma.j.issn.1673-422X.2015.06.019

Abstract

Abstract: Extensive in vitro studies reveal that multiple intracellular targets of Antrodia cinnomomea affect cell growth, apoptosis, angiogenesis, invasion and metastasis. These intracellular targets include tumor suppressor gene, cell cycle regulatory protein, transcription factor, angiogenic and metastatic factors, and apoptotic and survival regulators. In addition, Antrodia cinnomomea has immunomodulatory propertie, which plays an anti-cancer effect indirectly by means of enhancing immunity.

Key words: Liver neoplasms, Cell cycle, Apoptosis, Transcription factors, Antrodia cinnamomea

Chen Qingfa, Zhao Zongjie, Xie Haitao, Zhang Xiangyang, Wang Pengting. Research progress of Antrodia cinnomomea on the anti-hepatocarcinoma mechanism[J]. Journal of International Oncology, 2015, 42(6): 469-471.

References

［1］ Athar M, Back JH, Kopelovich L, et al. Multiple molecular targets of resveratrol: anticarcinogenic mechanisms［J］. Arch Biochem Biophys, 2009, 486(2): 95-102. ［2］ Song TY, Hsu SL, Yen GC. Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture［J］. J Ethnopharmacol, 2005, 100(1-2): 158-167. ［3］ Lin YW, Chiang BH. 4acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels［J］. J Agric Food Chem, 2011, 59(16): 8625-8631. ［4］ Chiang PC, Lin SC, Pan SL, et al. Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways［J］. Biochem Pharmacol, 2010, 79(2): 162-171. ［5］ Seitz SJ, Schleithoff ES, Koch A, et al. Chemotherapyinduced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway［J］. Int J Cancer, 2010, 126(9): 2049-2066. ［6］ Ao ZH, Xu ZH, Lu ZM, et al. Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases［J］. J Ethnopharmacol, 2009, 121(2): 194-212. ［7］ Kuo PL， Hsu YL， Cho CY， et al. Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpaindependent pathways in Hep 3B cells［J］. Food Chem Toxicol, 2006, 44(8): 1316-1326. ［8］ Hsieh YC, Rao YK, Wu CC, et al. Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidantmediated cofilin and Baxtriggered mitochondrial pathway［J］. Chem Res Toxicol, 2010, 23(7): 1256-1267. ［9］ Hsieh YC, Rao YK, WhangPeng J, et al. Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway［J］. J Agric Food Chem, 2011, 59(20): 10943-10954. ［10］ Song TY, Hsu SL, Yeh CT, et al. Mycelia from Antrodia camphorata in submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway［J］. J Agric Food Chem, 2005, 53(14): 5559-5564. ［11］ Fullar A, Kovalszky I, Bitsche M, et al. Tumor cell and carcinomaassociated fibroblast interaction regulates matrix metalloproteinases and their inhibitors in oral squamous cell carcinoma［J］. Exp Cell Res, 2012, 318(13): 1517-1527. ［12］ Weng CJ, Yen GC. Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro antiinvasive and in vivo antimetastatic activities［J］. Cancer Metastasis Rev, 2012, 31(12): 323-351. ［13］ Geethangili M, Tzeng YM. Review of pharmacological effects of antrodia camphorata and its bioactive compounds［J］. Evid Based Complement Alternat Med, 2011, 2011: 212641. ［14］ Takeuchi S, Wang W, Li Q, et al. Dual inhibition of Met kinase and angiogenesis to overcome HGFinduced EGFRTKI resistance in EGFR mutant lung cancer［J］. Am J Pathol, 2012, 181(3): 1034-1043. ［15］ Gafton B, Porumb V, Ungurianu S, et al. Hepatocellular carcinoma: insights in the biological treatment beyond sorafenib［J］. J BUON, 2014, 19(4): 858-866. ［16］ Liu YM, Liu YK, Lan KL, et al. Medicinal fungus antrodia cinnamomea inhibits growth and cancer stem cell characteristics of hepatocellular carcinoma［J］. Evid Based Complement Alternat Med, 2013, 2013: 569737. ［17］ Wang Z, Jiang Y, Guan D, et al. Critical roles of p53 in epithelialmesenchymal transition and metastasis of hepatocellular carcinoma cells［J］. PLoS One, 2014, 8(9): e72846.

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