Molecular mechanism of long non-coding RNAs in tumor drug resistance

doi:10.3760/cma.j.issn.1673-422X.2015.06.010

Abstract

Abstract: Long non-coding RNAs (lncRNAs) are closely related to the tumorigenesis, proliferation, metastasis and clinical outcome, whihc play important roles in the process of drug resistance of many tumor cells. Recently, research indicates that many lncRNAs regulate drug resistance of tumor cells through a variety of signaling pathways both in vitro and in vivo. Furthermore, it is also found that after blocking the relevant targets can reverse this chemoresistance.

Key words: RNA, Neoplasms, Drug tolerance, Signal transduction

Lian Yifan, Wang Keming. Molecular mechanism of long non-coding RNAs in tumor drug resistance[J]. Journal of International Oncology, 2015, 42(6): 439-441.

References

［1］ Milhem MM, Knutson T, Yang S, et al. Correlation of MTDH/AEG1 and HOTAIR expression with metastasis and response to treatment in sarcoma patients［J］. J Cancer Sci Ther, 2011, S5(4): 4. ［2］ Amit D, Hochberg A. Development of targeted therapy for a broad spectrum of cancers (pancreatic cancer, ovarian cancer, glioblastoma and HCC) mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2 P4 regulatory sequences［J］. Int J Clin Exp Med, 2012, 5(4): 296-305. ［3］ Pickard MR, MourtadaMaarabouni M, Williams GT. Long noncoding RNA GAS5 regulates apoptosis in prostate cancer cell lines［J］. Biochim Biophys Acta, 2013, 1832(10): 1613-1623. ［4］ Jiang M, Huang O, Xie Z, et al. A novel long noncoding RNAARA: adriamycin resistanceassociated［J］. Biochem Pharmacol, 2014, 87(2): 254-283. ［5］ Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities［J］. Nat Rev Cancer, 2009, 9(6): 400-414. ［6］ Grosset AA, Labrie M, Gagné D, et al. Cytosolic galectin7 impairs p53 functions and induces chemoresistance in breast cancer cells［J］. BMC Cancer, 2014, 14: 801. ［7］ Chen J, Lu H, Yan D, et al. PAK6 increase chemoresistance and is a prognostic marker for stage Ⅱ and Ⅲ colon cancer patients undergoing 5-FU based chemotherapy［J］. Oncotarget, 2015, 6(1): 355-367. ［8］ Li B, Gao Y, Rankin GO, et al. Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53dependent pathway in cisplatinresistant ovarian cancer cells［J］. Cancer Lett, 2015, 356(2 Pt B): 418-433. ［9］ Rinn JL, Kertesz M, Wang JK, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs［J］. Cell, 2007, 129(7): 1311-1323. ［10］ Liu Z, Sun M, Lu K, et al. The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21WAF1/CIP1 expression［J］. PLoS One, 2013, 8(10): e77293. ［11］ Zhang H, Cai K, Wang J, et al. MiR7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway［J］. Stem Cells, 2014, 32(11): 2858-2868. ［12］ Coller HA, Grandori C, Tamayo P, et al. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion［J］. Proc Natl Acad Sci USA, 2000, 97(7): 3260-3265. ［13］ Mikhail S, Zeidan A. Stem cells in gastrointestinal cancers: the road less travelled［J］. World J Stem Cells, 2014, 6(5): 606-613. ［14］ Polakis P. Wnt signaling in cancer［J］. Cold Spring Harb Perspect Biol, 2012, 4(5): a008052. ［15］ Hu T, Li C, Cao Z, et al. Myristoylated Naked2 antagonizes Wntbetacatenin activity by degrading Dishevelled1 at the plasma membrane［J］. J Biol Chem, 2010, 285(18): 13561-13568. ［16］ Yang Y, Li H, Hou S, et al. The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in nonsmallcell lung cancer cell［J］. PLoS One, 2013, 8(5): e65309. ［17］ Fan Y, Shen B, Tan M, et al. Long noncoding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling［J］. FEBS J, 2014, 281(7): 1750-1758. ［18］ Wang Y, Chen W, Yang C, et al. Long noncoding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer［J］. Int J Oncol, 2012, 41(1): 276-284. ［19］常冰梅, 姜蓬垒. PI3KAkt信号通路与肿瘤化疗耐药性［J］. 国际肿瘤学杂志, 2014, 41(5): 324-327. ［20］ Matouk IJ, Raveh E, Abulail R, et al. Oncofetal H19 RNA promotes tumor metastasis［J］. 2014, 1843(7): 1414-1426. ［21］ Tsang WP, Kwok TT. Riboregulator H19 induction of MDR1associated drug resistance in human hepatocellular carcinoma cells［J］. Oncogene, 2007, 26(33): 4877-4881. ［22］ Wang Y, Zhang D, Wu K, et al. Long noncoding RNA MRUL promotes ABCB1 expression in multidrugresistant gastric cancer cell sublines［J］. Mol Cell Biol, 2014, 34(17): 3182-3193. ［23］ Takahashi K, Yan IK, Kogure T, et al. Extracellular vesiclemediated transfer of long noncoding RNA ROR modulates chemosensitivity in human hepatocellular cancer［J］. FEBS Open Bio, 2014, 4: 458-467. ［24］ Tsang WP, Wong TW, Cheung AH, et al. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR［J］. RNA, 2007, 13(6): 890-898. ［25］ Ding J, Li D, Gong M, et al. Expression and clinical significance of the long noncoding RNA PVT1 in human gastric cancer［J］. Onco Targets Ther, 2014, 7: 1625-1630. ［26］ You L, Chang D, Du HZ, et al. Genomewide screen identifies PVT1 as a regulator of Gemcitabine sensitivity in human pancreatic cancer cells［J］. Biochem Biophys Res Commun, 2011, 407(1): 1-6. ［27］ Tseng YY, Moriarity BS, Gong W, et al. PVT1 dependence in cancer with MYC copynumber increase［J］. Nature, 2014, 512(7512): 82-86.

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