Cytokeratin 14 and cancer

doi:10.3760/cma.j.issn.1673-422X.2015.06.009

Abstract

Abstract: Cytokeratin 14 (CK14) has a different degree of expression in NSCLC, breast cancer, cervical cancer, esophageal cancer and other tumors, except in the normal basal cells. CK14 is mainly expressed in the peripheral part of the tumor, which is rarely expressed in the nonaggressive part. Usually the higher malignant of the tumor has the more expression of CK14. Given all that, CK14 gene plays an important role in the tumor progression and metastasis in a variety of tumors, which can be considered as an biomarker being used in the diagnosis, treatment and prognosis evaluation.

Key words: Keratin 14, Tumor markers, biological, Neoplasms

Zhang Weiquan, Zhao Xiaogang. Cytokeratin 14 and cancer[J]. Journal of International Oncology, 2015, 42(6): 436-438.

References

［1］ Bragulla HH, Homberger DG. Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia［J］. J Anat, 2009, 214(4): 516-559. ［2］ Magin TM, Vijayaraj P, Leube RE. Structural and regulatory functions of keratins［J］. Exp Cell Res, 2007, 313(10): 2021-2032. ［3］薛丽燕, 邹霜梅, 郑闪, 等. 成束蛋白和细胞角蛋白14在多种肿瘤组织中的表达及其鉴别诊断意义［J］. 中华肿瘤杂志, 2010, 32(11): 838-844. ［4］ Linskey KR, Gimbel DC, Zukerberg LR, et al. BerEp4, cytokeratin 14, and cytokeratin 17 immunohistochemical staining aid in differentiation of basaloid squamous cell carcinoma from basal cell carcinoma with squamous metaplasia［J］. Arch Pathol Lab Med, 2013, 137(11): 1591-1598. ［5］魏志敏, 谷海燕, 赵洁, 等. 乳腺癌的分子分型与临床病理特征的关系［J］. 癌症进展, 2010, 8(6): 622-625. ［6］ Jemal A, Bray F, Center MM, et al. Global cancer statistics［J］. CA Cancer J Clin, 2011, 61(2): 69-90. ［7］ Tsubokawa F, Nishisaka T, Takeshima Y, et al. Heterogeneity of expression of cytokeratin subtypes in squamous cell carcinoma of the lung: with special reference to CK14 overexpression in cancer of highproliferative and lymphogenous metastatic potential［J］. Pathol Int, 2002, 52(4): 286-293. ［8］ Chen Y, Cui T, Yang L, et al. The diagnostic value of cytokeratin 5/6, 14, 17, and 18 expression in human nonsmall cell lung cancer［J］. Oncology, 2011, 80(5-6): 333-340. ［9］段楚骁, 付圣灵, 付向宁. 联合检测在NSCLC中鉴别诊断的价值［J］. 临床肺科杂志, 2015, 20(1): 115-118. ［10］段楚骁, 李梦晨, 付圣灵, 等. CK14在低分化NSCLC中区分鳞癌和腺癌的意义［J］. 中华肺部疾病杂志: 电子版, 2014, 7(6): 651-652. ［11］ Cheung KJ, Gabrielson E, Werb Z, et al. Collective invasion in breast cancer requires a conserved basal epithelial program［J］. Cell, 2013, 155(7): 1639-1651. ［12］赵鸿, 薛娣, 冷冬妮. 受体三阴性乳腺癌中CK14和EGFR的检测及临床意义［J］. 临床医学工程, 2011, 18(6): 862-863. ［13］陶淑芳, 杨春玉, 彭雪峰, 等. CK5/6、CK14、SMA、P53、Ki67、ER在乳腺导管内增生性病变中的表达及意义［J］. 南昌大学学报: 医学版, 2012, 52(4): 45-49. ［14］ Wang S, Qiao Y. Implementation of cervical cancer screening and prevention in Chinachallenges and reality［J］. Jpn J Clin Oncol, 2015, 45(1): 7-11. ［15］李晓霞, 李连宏. P63、CK14及CK8在宫颈病变组织中的表达及其相关性研究［J］. 世界最新医学信息文摘, 2013, 13(10): 194-195. ［16］肖艳景, 张全武, 娄欣, 等. CK10、CK14、CK17、P16在宫颈不成熟鳞状化生及宫颈上皮内瘤变中的表达［J］. 医药论坛杂志, 2011, 31(22): 132-134. ［17］张昆. CK14和HPV16E6 mRNA 在早期宫颈癌患者外周血中的表达与宫颈癌微转移的关系［D］. 蚌埠: 蚌埠医学院, 2011. ［18］史志猛. 食管鳞状细胞癌Shh与CK14的表达及意义［D］. 太原: 山西医科大学, 2013. ［19］薛丽燕. 与食管鳞癌发生发展相关的多种蛋白表达分析［D］. 北京: 中国协和医科大学, 2005. ［20］ Takikita M, Hu N, Shou JZ, et al. Fascin and CK4 as biomarkers for esophageal squamous cell carcinoma［J］. Anticancer Res, 2011, 31(3): 945-952. ［21］ Ju F, Lu L, Zhao QY, et al. Systematic analysis of gene expression and molecular interactions in cardiac and noncardiac gastric carcinomas［J］. Hepatogastroenterology, 2014, 61(134): 1835-1842. ［22］于观贞, 陈颖. CK7、CKl4、CKl9和 CK20在胃肠癌转移诊断中价值的新发掘［J］. 肿瘤, 2006, 26(11): 10151019. ［23］ Lopes LF, Bacchi CE. Cytokeratin expression in gastrointestinal stromal tumor: a clinicopathologic and immunohistochemical study of 687 cases［J］. Appl Immunohistochem Mol Morphol, 2012, 20(1): 8-12. ［24］ Wang Y, Guo P, Liu QS, et al. Clinicopathologic characteristics of basal cell carcinoma of the prostate: analysis of 5 cases and review of the literature［J］. Zhonghua Nan Ke Xue, 2014, 20(2): 160-164. ［25］孙莉, 董艳光, 徐志秀, 等. 七种细胞角蛋白在皮肤上皮性肿瘤中的表达［J］. 中华皮肤科杂志, 2006, 39(2): 68-70. ［26］王瑜, 郭鹏, 刘清松, 等. 前列腺基底细胞癌5例临床病理特征分析并文献复习［J］. 中华男科学杂志, 2014, 20(2): 160-164.

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