Functions of platelets in tumor growth and metastasis

doi:10.3760/cma.j.issn.1673-422X.2014.09.002

Abstract

Abstract: Increases of platelet amount and activation are associated with tumor metastasis. Current studies reveal that platelets participate in the process of tumor metastasis via promoting immune escape, adhesion and angiogenesis. The direct interactions between platelets and tumor cells are also founded as an important determinant in metastasis. The functions of platelets in tumor progression and metastasis suggest that platelets could be served as new potential targets for cancer treatment.

Key words: Blood platelets, Neoplasms, Neoplasm metastasis

Zhang Tianjia, Dang Suying. Functions of platelets in tumor growth and metastasis[J]. Journal of International Oncology, 2014, 41(8): 645-647.

References

［1］ Khorana AA, Connolly GC. Assessing risk of venous thromboembolism in the patient with cancer［J］. J Clin Oncol, 2009, 27(29): 4839-4847. ［2］ Lyman GH, Khorana AA. Cancer, clots and consensus: new understanding of an old problem［J］. J Clin Oncol, 2009, 27(29): 4821-4826. ［3］ Bambace NM, Holmes CE. The platelet contribution to cancer progression［J］. J Thromb Haemost, 2011, 9(2): 237-249. ［4］ Gay LJ, FeldingHabermann B. Contribution of platelets to tumor metastasis［J］. Nat Rev Cancer, 2011, 11(2): 123-134. ［5］ Zhang W, Dang S, Hong T, et al. A humanized singlechain antibody against beta 3 integrin inhibits pulmonarymetastasis by preferentially fragmenting activated platelets in the tumor microenvironment［J］. Blood, 2012, 120(14): 2889-2898. ［6］ Rao AK, Rao DA. Platelets signal and tumors take off［J］. Blood, 2012, 120(24): 4667-4668. ［7］ Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelialmesenchymallike transition and promotes metastasis［J］. Cancer Cell, 2011, 20(5): 576-590. ［8］ Versteeg HH, Schaffner F, Kerver M, et al. Proteaseactivated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice［J］. Cancer Res, 2008, 68(17): 7219-7227. ［9］ Jain S, Zuka M, Liu J, et al. Platelet glycoprotein Ⅰb alpha supports experimental lung metastasis［J］. Proc Natl Acad Sci USA, 2007, 104(21): 9024-9028. ［10］ Kopp HG, Placke T, Salih HR. Plateletderived transforming growth factorbeta downregulates NKG2D thereby inhibiting natural killer cell antitumor reactivity［J］. Cancer Res, 2009, 69(19): 7775-7783. ［11］ Lubli H, Borsig L. Selectins promote tumor metastasis［J］. Semin Cancer Biol, 2010, 20(3): 169-177. ［12］ Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: the end game［J］. Nat Rev Mol Cell Biol, 2010, 11(4): 288-300. ［13］ Kuo YC, Su CH, Liu CY, et al. Transforming growth factorbeta induces CD44 cleavage that promotes migration of MDAMB435s cells through the upregulation of membrane type 1matrix metalloproteinase［J］. Int J Cancer, 2009, 124(11): 2568-2576. ［14］ Smyth SS, McEver RP, Weyrich AS, et al. Platelet functions beyond hemostasis［J］. J Thromb Haemost, 2009, 7(11): 1759-1766. ［15］ HoTinNoé B, Goerge T, Cifuni SM, et al. Platelet granule secretion continuoussly prevents intratumor hemorrhage［J］. Cancer Res, 2008, 68(16): 6851-6858.

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