Journal of International Oncology ›› 2014, Vol. 41 ›› Issue (4): 241-243.doi: 10.3760/cma.j.issn.1673-422X.2014.04.001

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Roles and resistance mechanisms of survivin in tumor

 ZHENG  Ying, CHEN  Qin, ZHANG  Bin, CAO  Xu-Chen   

  1. Tianjin Medical University Cancer Institute and Hospital; National Clinical Research of Cancer; Key Laboratory of Breast Cancer Prevention and Therapy of Tianjin; Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Tianjin 300060, China
  • Online:2014-04-08 Published:2014-03-17
  • Contact: CAO Xu-Chen E-mail:cxc@medmail.com.cn

Abstract: Drug resistance in tumor treatment is an important factor that affects disease outcome. A lot of researches show that survivin can inhibit tumor cell apoptosis, regulate cell cycle, promote angiogenesis and tumor metastasis. The interactions among survivin, genes and proteins can influence the drug resistance of tumor cells.

Key words: Drug resistance, neoplasm, Neoplasms, Multidrug resistanceassociated proteins, Survivin