Journal of International Oncology ›› 2014, Vol. 41 ›› Issue (2): 84-87.doi: 10.3760/cma.j.issn.1673-422X.2014.02.002

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Role of endoplasmic reticulum stress in tumor progression

Ma Ruijin, Yang Yu   

  1. Department of Oncology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
  • Received:2013-09-24 Revised:2014-01-02 Online:2014-02-08 Published:2014-01-26
  • Contact: Yang Yu E-mail:yangy@medmail.com.cn

Abstract: Endoplasmic reticulum stress (ERS) as a cell stress, can be activated in a variety of cells and situations. In recent years, researches show that ERS exists in many kinds of tumor cells so as to play a number of roles in inducing cell apoptosis, autophagymediated apoptosis, immunogenic cell death, promoting tumor cell survival, regulating the cell cycle. So study on ERS is helpful to understand the development and the outcome of tumor.

Key words: Neoplasms, Apoptosis, Autophagy, Endoplasmic reticulum stress