Application of cold plasma in cancer therapy

doi:10.3760/cma.j.issn.1673-422X.2014.01.008

Abstract

Abstract: Research shows that cold plasma has therapeutic effect on hepatocellular carcinoma, melanoma, brain tumors, colorectal cancer, lung cancer and so on. The main mechanisms are as follows: the plasma can increase the levels of nitric oxide and reactive oxygen species in tumor cells, lead to DNA damage and mitochondrial dysfunction, activate mitochondrial apoptosis pathway, change the ratio Bax/Bcl-2, activate apoptosis proteins caspase3, 9, accompanied by cell cycle arrest (G2-M phase or S phase), eventually induce cell growth arrest and apoptosis; increase βcatenin phosphorylation, lead to βcatenin degradation, inhibit the expressions of integrin α2, integrin α4 and focal adhesion kinase on the cell surface, destroy cancer cells adhesion and reduce cell migration and invasion activities.

Key words: Apoptosis, Antineoplastic protocols, Plasma

Hu Chao, Zhou Juying. Application of cold plasma in cancer therapy[J]. Journal of International Oncology, 2014, 41(1): 24-27.

References

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